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Alumni Helen Smith (B.S

Dermatol 71, 11101116

Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures

Loss of NAD + levels results in impairment of mitochondria function, which leads to failure of essential metabolic processes (Klimova and Kristian, 2019

Given that low lactate dehydrogenase levels represent a high mitochondrial metabolic state, this finding is consistent with the observation that cells with high levels of lipoylated TCA enzymes and a hyperactive mitochondrial respiratory rate are more sensitive to elesclomol