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Yet, we demonstrate that impaired Cl - extrusion underlies the failure of L838,417 to induce analgesia at high doses due to a resulting collapse in Cl - gradient, dramatically limiting the benzodiazepine therapeutic window

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Mutational analysis reveals that all-trans-retinoic acid, 9-cis-retinoic acid, and antagonist interact with distinct binding determinants of RARalpha

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PLoS One 9: e110948