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doi: 10.1016/j.clnesp.2024.06.026 21

Dose discipline: Adhere strictly to conservative dosing protocols

Therefore, there is an urgent need to identify novel, safe, and multi-targeted agents for the prevention and treatment of these diseases (Bordoloi et al., 2016

they are likely to promote apoptosis (programmed cell death), to cause changes in protein aggregation, and almost certainly to contribute to the mechanism of cataractogenesis.92 Cytoplasmic pH in lens cells has been reported in the range 6.9 to 7.2, which is slightly more acidic than aqueous humor.93,94 The concentration of free amino acids in the mammalian lens is higher than that in the aqueous humor, vitreous, or plasma.95,96 There is good evidence that amino acids are transported into the lens by means of an energy-dependent carrier system

This section will therefore briefly summarize what is known from mammalian data before presenting the limited status quo from research in fish

Moreover, glutaminolysis also contributes to the production of antioxidative molecules like glutathione and NADPH [72]