what does glutathione have to do with the human process Metabolism - an overview Glutathione – Understanding the Powerful

10.1016/j.cmet.2019.01.020 Summary Keywords xCT transporter, cysteine, lipid peroxides, glutathione, ferroptosis, tumor-resistance Citation Daher B, Vueti M and Pouyssgur J (2020) Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

Although its coverage is smaller, it is more cost-effective and the data volume is more controllable, thus it is widely applied in clinical research

Superoxide is known to denature enzymes, oxidize lipids, and fragment DNA

Glutathione is part of many defined enzymes such as glutathione peroxidase, glutathione S transferases, glutathione dihydroascorbate reductase

Rather than acting as a parallel or secondary layer of resistance, microenvironmental cues continuously interact with intracellular signaling, metabolic, and epigenetic programs within melanoma cells, potentially facilitating reversible survival states during treatment

2013), which is probably induced by higher ROS accumulation in older leaves, this high and comparatively stable glutathione level seems to be crucial for mitochondria and cell functioning and viability under non-stress and stress conditions (Zechmann 2017, 2020)