glutathione-synthesizing enzymes glutathione biosynthesis pathway Figure 2 from SYNTHESIS Two-step enzymatic reaction of glutathione – Scheme of enzymes involved in

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Introduction It is serendipitous (or perhaps indicative of hard work) that the Nobel prize winner Szent-Gyorgyi discovered both ascorbic acid (vitamin C) and the flavonoid quercetin (at the time labeled vitamin P) ( Vitamin C exerts its antiviral properties by supporting lymphocyte activity, increasing interferon- production, modulating cytokines, reducing inflammation, improving endothelial dysfunction, and restoring mitochondrial function ( in vitro effects, as we previously discussed ( Quercetin (also known as 3,3,45,7-pentahydroxyflavone) is a widely distributed plant flavonoid, found in several vegetables, leaves, seeds, and grains, where it is conjugated with residual sugars to form quercetin glycosides ( In this review we collate the evidence of the antiviral properties of quercetin, describe its biologic action and pharmacokinetics profile, expand on our previous review of vitamin C, discuss their synergistic actions, and propose this experimental multi-drug approach for the prevention and treatment of SARS-CoV-2/COVID-19 pandemic

Thai J Pharm Sci (2010) 34(2):1468

10.1021/acs.jnatprod.7b00463 269 SungP