glutathione lupus treatment Frontiers What is Glutathione? What are

doi: 10.1136/ard-2024-226017 127 AlbachFNMinopoulouIWilhelmABiesenRKleyerAWiebeEet al

Abbreviations ACE: angiotensin-converting enzyme ACh: acetylcholine ADMA: asymmetric dimethyl-L-arginine ATII: angiotensin II BH 4 : tetrahydrobiopterin cGKI: cGMP-dependent protein kinase cGMP: cyclic guanosine monophosphate CTP CH-I: GTP cyclohydrolase I DDAH: dimethylarginine dimethylaminohydrolase DETC: diethylthiocarbamate DHFR: dihydrofolate reductase DOCA: deoxycorticosterone acetate eNOS: endothelial nitric oxide synthase FMD: flow-mediated dilation LDL: low-density lipoprotein L-NAME: N G -nitro-L-arginine methyl ester NO: nitric oxide NTG: nitroglycerin ONOO : peroxynitrite PDE1A1: phosphodiesterase 1A1 PKC: protein kinase C PRMT: protein arginine N -methyltransferase ROS: reactive oxygen species sGC: soluble guanylyl cyclase SHR: spontaneously hypertensive rats SNP: sodium nitroprusside SOD: superoxide dismutase STZ: streptozotocin VASP: vasodilator-stimulated phosphoprotein

This holds true for tumors baring KRAS mutations for instance, which are generally difficult to treat, being resistant to targeted anti-EGFR therapy amongst others

These toxicities are mostly due to the conditioning regimen used prior to HSCT and several strategies have been introduced to improve the clinical outcome 23,24,25,26,27,28,29,30,31

10.1007/s10067-020-05178-1 114 KumarA.SinghB.MishraJ.SahS

I.PiluduM.et al (2021)