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Conclusion: PFIC1-specific hiHeps can recapitulate the dysfunctional activity of FIC1 and support the hypothesis that dysregulated FXR contributes to the PFIC1 phenotype

Similarly, excessive level of HBO1 mRNA in GC tissues and its negative correlation with GC patient survival indicated that HBO1 might act as a potential biomarker to predict patient prognosis [30]

In previous studies, it was shown that N-acetyl-L-cysteine, L-2-oxothiazolidine-4-carboxylate, as well as 2(R,S)-n-propyl-, 2(R,S)-n-pentyl and 2(R,S)-methyl-thiazolidine-4R-carboxylate can protect mice from heptatotoxic dosages of acetaminophen

Visceral fat is a type of body fat that surrounds internal organs and is often linked to serious health concerns in adults

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In conclusion, copper chelation therapy presents a promising avenue for cancer treatment due to its ability to exploit the increased demand for copper in tumor cells, affect cellular metabolic processes, and enhance the effectiveness of other cancer therapies