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doi: 10.3390/ruminants1020012 39 MiqueoEMattioliGAMooreDPBilbaoMGMoranKDRellingAE

Most people eating a mixed diet get well above the adequate intake

As previously mentioned, examples of longevity resulting from disruption of the GH/IGF-1 and/or insulin signaling pathway are mainly derived from early life manipulations 6,17,18 , whereas brief exposure to GH (and IGF-1) treatment early in development is sufficient to partially abrogate the exceptional longevity of Ames Dwarf mice 20