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In addition, 18 F-FDG PET imaging allowed to show the presence of extensive and durable hypometabolism in several brain regions of long COVID patients (176, 177), in particular in the pons and the right amygdala (178)

Amino Acids 2012 , 736837 (2012)

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In this context, cells reroute glutamine into the reductive carboxylation pathway: NADP + -dependent isocitrate dehydrogenase runs in reverse to convert -ketoglutarate (from glutamine) into citrate, which is cleaved to acetyl-CoA for fatty acid synthesis 98