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10.1021/ja411006a 112 StatzerC.MengJ.VenzR.BlandM.Robida-StubbsS.PatelK.et al (2022)

Most of the rapid increase in peak plasma radioactivity was related to the parent drug, implying a low level of first pass metabolism

Blood-brain barrier transport, plasma pharmacokinetics, and neuropathology following chronic treatment of the rhesus monkey with a brain penetrating humanized monoclonal antibody against the human transferrin receptor

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This hypothesis was supported by the observation that such a combined treatment resulted in beneficial effects in 9 out of 12 migraine patients