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Since endocytosis of NPs by the BBB endothelial cells seems to be predominantly mediated by receptors, many efforts have been made with SLN surface functionalization to enhance their CNS availability (Kuo et al., 2019

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et al., 2012), thus supporting the idea that enhanced mGluR1/5 cascades are causative for some symptoms of the disease

Combining techniques such as NMR, XFEL, Artificial Intelligence Molecular Dynamics Simulation (AI-MD), and physiologically relevant models, such as organoid or single-cell models, will provide a more comprehensive and biologically meaningful understanding of protein conformational dynamics in complex herbal formulations

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