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Four PK isoenzymes are present in mammalian tissues: PK-M1 (in skeletal muscle), PK-M2 (in leukocytes, kidney, adipose tissue, and lungs), PK-L (in liver), and PK-R (in red blood cells)

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Oxidative stress and mitochondrial damage are inextricably linked to RA development, and our focus was on the mitochondrial regulation of metabolism affecting the disease process of RA

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