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Senolytic drugs: from discovery to translation Kirkland JL, Tchkonia T Journal of Internal Medicine (2020) This comprehensive review from the Mayo Clinic's leading senescence researchers places FOXO4-DRI within the broader context of senolytic drug development and clinical translation

Although we found an optimized sequence for the FOXO4 FHD-p53 TAD interaction, it did not show senolytic activity by itself (Figure