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Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, Torino F, Banna GL, Tonini G, Libra M

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The following is our policy with regard to rounding of the wage data (dollar amounts, hours, and other numerical values) in the calculation of the unadjusted and adjusted wage index, as finalized in the FY 2020 IPPS/LTCH final rule (84 FR 42306, August 16, 2019)

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In sALS patients, deregulation of the cellular redox systems has been suggested by higher free radical levels found in the blood and serum of patients[32, 73], and evidence of oxidative damage includes the increase in protein carbonyls[34, 35, 74, 75], 8-OHdG[47, 49], MDA-modified proteins[34], 4-HNE protein conjugates[36, 76], and nitrotyrosine products[7779] in the spinal cord

Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway