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GHK-Cu is marketed for wound healing and connective tissue remodeling, while endocrine-active compounds such as growth hormone secretagogues and IGF-1 analogs are used to augment recovery and performance (Pickart and Margolina 2018

Purified rat acid-labile subunit and recombinant human insulin-like growth factor (IGF)-binding protein-3 can form a 150-kilodalton binary complex in vitro in the absence of IGFs