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22,208,209 It shows the imbalance in cortical-subcortical limbic regions with decreased GABAergic signaling and increased glutamatergic signaling

It is postulated that AGEs participate in the pathological mechanism of cardiovascular disease, nephropathy, rheumatoid arthritis, dysfunctions in bone remodelling and neurological diseases (for example, Alzheimer's and Parkinson's disease), cancer growth, metastasis and other degenerative diseases (9,20-22)