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[73] Long-term administration of D + Q in C57BL6 mice led to compartment-specific effects on delaying disc degeneration, alleviating senescence markers, and reducing SASP factors

However, nucleic acid therapeutics are inherently susceptible to degradation, require stringent dose control to minimize off-target effects, and typically modulate only a single pathway, such as VEGF upregulation-limiting their therapeutic scope