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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

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The tirzepatide molecule itself has extensive clinical backing through the SURMOUNT and SURPASS trial programs

Importantly, there was an apparent improvement in cardiac function in the cAtg3-KO mice following treatment [8]

Smith, Ross Howden, Wendy M