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Drugs targeting this toxicity (Memantine in AD, Amantadine in PD and Riluzole in ALS) have modest clinical benefit

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Whether it is the significant accumulation of iron in the substantia nigra of Parkinsons disease patients or the deficiency of iron in the striatum of individuals with ADHD, both indicate that iron metabolism imbalance is a critical factor in understanding the neuropathological changes underlying these conditions (9)

Human mitochondrial DNA is a maternally inherited, circular genome approximately 16.6 kilobases in length that encodes 37 genes, including 13 polypeptides essential for oxidative phosphorylationcomprising subunits of complex I (NADH dehydrogenase), III (bc1 complex), IV (cytochrome c oxidase), and V (ATP synthase)as well as 22 transfer RNAs and the 12 S and 16 S ribosomal RNAs required for mitochondrial protein synthesis

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Krall, A