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The incidence and mortality of cancer are increasing year by year, and it is estimated that by 2040, the global cancer burden will reach 28.4 million people, an increase of 47% over 2020 (1)

Together, GGT and ChaC1 regulate both intracellular and extracellular GSH degradation, emerging as promising prognostic markers and therapeutic targets for specific types of tumor such as liver cancer (172,173), breast cancer (74) and so on

High volume ECD and DCD centers are expanding the donor pool without adversely impacting patient outcomes

Structural improvements lead to reduced discomfort during daily activities

One-step purification can achieve a purity of more than 95% of the target protein

However, both pAMPK and pACC levels were much lower in shGDH1 cells and not equally elevated as shCtrl cells during glucose starvation (Fig