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Feature · Product Review
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Description

This review aims to systematically expound on these dual physiological and pathological roles, arguing that such disease-specific metabolic alterations not only provide biomarkers but, more importantly, unveil targetable vulnerabilities, thereby positioning amino acid metabolism as a strategic frontier for developing novel therapeutics across liver diseases

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To identify the sensor Cys residues of KEAP1 involved in direct cysteinylation by free Cys, we incubated the recombinant purified KEAP1 with free Cys and determined by mass spectrometry that Cys residues 77, 151, 226, 288, 319, 489, 583, and 613 were modified by cysteinylation in vitro (Fig

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