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second, Fun30, SMARCAD1, and fission yeast Fft3 have a role in the maintenance of silent chromatin

Concretely, EC-derived lactate induces histone Kla, particularly H3K18la, which promotes the differentiation of bone mesenchymal stem cells (BMSCs) into osteoblasts by activating osteogenic genes such as COL1A2, COMP, ENPP1, and TCF7L2