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With overuse, there is documented concern around kidney stress

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Dysesthesia (Skin Sensitivity) A distinct side effect that has emerged primarily at higher doses of retatrutide is dysesthesia an altered, sometimes uncomfortable physical sensation on the skin, often described as mild tingling, burning, or hyper-sensitivity to touch

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Consequently, the 2024 American Gastroenterology Association (AGA) Rapid Clinical Practice Update recommends that management should depend on upper gastrointestinal symptoms