the combination index was less than 0.2 for all effective doses, with 19.8-fold and 5-fold shifts in the IC 50 (0.5 M for HG-3 and 0.38 M for MEC-1 cell line) ( Supplemental Table 3 , Supplemental Figure 8 )
Many patients combine oral supplements with IV therapy for optimal results
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doi: 10.5607/en.2015.24.2.103
However, larger trials have not consistently shown mortality benefit (Rank et al., Crit Care Med, 2000) [41]
Over the 52-week-long trial, hypomagnesemia (7.2%) was the most common treatment-related adverse event and mild to moderate constipation (6.3%) was the most common GI adverse event
