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Clinical Studies 14.1 Non-Squamous NSCLC Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed for injection in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

See How Your Own Numbers Work Out Enter your weight, sex, drinks, and time elapsed into the free Widmark-based BAC calculator then keep reading to see exactly how hydration status fits into the bigger picture

When circulating levels fall below optimal, the downstream effects are real and measurable: fatigue, poor concentration, slowed metabolism, and reduced resilience to illness

Because the production of anti-drug antibodies (ADAs) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics, immunogenicity an important factor in the toxicity profile of biotherapeutic proteins 16

Improved sleep quality reported as a positive effect due to melatonin-stimulating properties, but may cause drowsiness if injected in the morning

Author contributions Conceptualization: II, NA, and MM