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364 In an APP/PS1 mouse model of AD that carries human AD-linked mutations in APP and PSEN 1 genes, UA restored neuronal mitophagy, ameliorated cognitive decline, reduced A pathology, and mitigated neuroinflammation

Be mindful of other supplements that you are taking that may already include a blend of nutrients (e.g

10.1111/cas.14385 9

Air pollutants potentially affect MTHFR gene expression through genotoxicity and epigenetic modifications, leading to changes in DNA methylation patterns

This unbalanced regulation of the glutathione oxidation/reduction cycle indicates the existence of an alternative pathway to regenerate GSH from GSSG to maintain a stable GSSG/GSH ratio

This finding is supported by that of another study 36 , which reported the association of ER stress with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation