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This toxicity is the most common cause of acute liver failure in the United States, resulting in an estimated 56,000 hospital visits each year

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N6-methyladenosine (m 6 A) is the most prevalent internal chemical modification in eukaryotic RNA [6]

In response to Ang II stimulation, myocardin-related transcription factor A (MRTF-A) is recruited to the ET-1 promoter by c-Jun/c-Fos (AP-1), which alters the chromatin structure by modulating H3K9ac, H3K27ac, and H3K4me2/3 on the ET-1 promoter [113]

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