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We propose that IOP elevation initiates hypoxia that contributes to mitochondrial dysfunction, oxidative stress, impaired mitophagy and inflammation and that these processes are exacerbated by interactions between inflammation and mitochondrial dysfunctional (Figure 1)

As demonstrated in relevant studies, lactate can be transported to neurons and serve as an energy substrate, maintaining the transmembrane ion gradients required for axons to conduct action potentials

Maintain consistent sleep schedules and prioritize 79 hours of quality sleep per night

Sekhar and his colleagues have been studying mitochondrial function and glutathione for more than 20 years

Function and inhibitory mechanisms of multidrug efflux pumps

Live microscopy Data acquisition and analysis were performed using IncuCyte S3 Live Cell Analysis System (Sartorius)