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Several other conditions, including a history of pancreatitis, gallbladder disease, severe gastroparesis, severe kidney disease, diabetic retinopathy, and a history of an eating disorder, need extra clinical caution rather than being automatic exclusions

Cyanocobalamin is the most widely used form of vitamin B 12, and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract

These effects are typically mild to moderate, dose-dependent, and tend to diminish with continued use and proper dose escalation

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These studies will be critical for understanding the research utility of this pathway and identifying optimal applications for future investigational development