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[DOI] [PubMed] [Google Scholar] 153.Yu JY, Chuesiang P, Shin GH, Park HJ

Int J Rheum Dis

In KRAS-G12C models, the inhibitor MRTX1257 acted as a radiosensitiserenhancing radiotherapy-induced tumour control in vitro and in vivo, with the most durable effects observed in immunocompetent settings, consistent with an immune-mediated contribution to efficacy.130 Mechanistically related work shows that blocking the KRAS pathway downstream (eg, MEK inhibition) augments radiotherapy by boosting antitumor immunity, reinforcing the biological rationale for pairing KRAS-pathway blockade with radiation.131 Early clinical translation is underway

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EClinicalMedicine 43 , 101227 (2022)

This value exceeds previously reported values of 2.3, 5.2, and 3.0%, pointing out potential regional changes in M