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Why was AOD-9604 developed to be selective rather than using full growth hormone

Hepatology 66 , 11111124 (2017)

In general, the majority of the CD38 NADase catalytic activity will generate nicotinamide, and a nearly stoichiometric amount of ADPR with residual amounts of NAD being converted to cADPR and nicotinamide [34-35, 38-40, 58-60]

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Most patients notice early improvements within 24 weeks