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Since the 1990s, folate status and genetics have been linked to a plethora of diseases, many of which stem from impaired DNA-thymidylate and methylation pathways, and include adverse prenatal, oncogenic, cardiovascular and neurological outcomes

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Researchers are exploring innovative strategies for neurodegenerative disorders, with EGCG emerging as a promising compound

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Thus, overactive mTORC1 inhibits mitophagy, leading to the accumulation of dysfunctional mitochondria, which contributes to increased ROS production and reduced cellular energy efficiency