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This is manifested by marked abdominal distention with increase of intra-abdominal pressure

Oxidative stress and glutathione supplementation Richie et al

Senescent astrocytes switch from BDNF and IGF-1 production, which stimulate healthy neuronal growth, to TNF and IFN production, which trigger demyelination and inflammation of neurons 253,287,293,300

Consider: daily multivitamin, vitamin D 2,000-4,000 IU daily (most people are deficient), vitamin B12 if energy is low, calcium 1,000-1,200mg daily (especially for women), fiber supplement if constipated, protein powder if struggling to hit 80-100g daily from food

Intriguingly, the so-called M2 or alternatively activated macrophages have a different metabolic profile and inflammatory phenotype 87,88

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