E.g., l-tryptophan with isoelectric point of 5.65 is electrostatically repulsed at pH values of 7 from the negative charged nanoparticle surface (Fig
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Mead J, Turner JM, Macklem PT, Little JB
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12 Meanwhile, computational design approaches are accelerating the development of PROTACs and AUTACs, enabling targeted degradation of disease-associated proteins through UPS or autophagy, respectively
