glutathione ethyl ester treatment Ester, Biotin Amide (BioGEE) (Glutathiolation Detection Reagent) Tumor-targeted glutathione oxidation catalysis with

doi:10.3233/VES-130498 Bhattacharyya N, Gubbels SP, Schwartz SR, et al

Hensley ML, Hagerty KL, Kewalramani T, Green DM, Meropol NJ, Wasserman TH, Cohen GI, Emami B, Gradishar WJ, Mitchell RB, Thigpen JT, Trotti A 3rd, von Hoff D, Schuchter LM

Oxidation of the Cys residue in the active site of PTPs by ROS abrogates its nucleophilic properties, thereby inhibiting PTP activity (87)

Since the suppressed AKT is related with exaggerated oxidative stress, neuroinflammation and neuronal apoptosis (Luo et al

A minor portion of the drug is metabolized in the liver by the cytochrome P450 enzymes (primarily CYP2E1) to the reactive and toxic APAP intermediate, N -acetyl-p-benzoquinone imine (NAPQI) (Patten et al

Disclosure of interest: Xinjie Gao: nothing to disclose Poster Session I - INTRACRANIAL HEMORRHAGE 02.00 - INTRACRANIAL HEMORRHAGE - 02.01 - INTRACEREBRAL HAEMORRHAGE P158 - ESOC25-1869 ACCURACY OF AUTOMATED HEMORRHAGE SUBTYPE DETECTION IN SUSPECTED INTRACEREBRAL HEMORRHAGE James Garrard 1,2 , Artem Kaliaev 3 , Asim Mian 3 , Chad Farris 3 , Pau Bellot 1 , Olivier Joly 1 , Zoe Woodhead 1 , James Briggs 1,4 , Davide Carone *1 , George Harston 1,2 , Mohamad Abdalkader 3 1 Brainomix, OXFORD, United Kingdom, 2 Oxford University Hospitals, OXFORD, United Kingdom, 3 Boston Medical Centre, Boston, United States, 4 Royal Berkshire Hospital, Reading, United Kingdom Background and Aims: Early identification of patients with intracerebral hemorrhage (ICH) is thought to be critical to improve outcomes through earlier implementation of evidence-based care-bundles