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The most widely accepted hypothesis suggests that chronic inflammatory reaction at the site of injections provides a trigger for subsequent malignant transformation

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Side effects are rare and usually mild

In sum, the safety observations support the concept that the IRR, the target of ARA 290, is induced only by injury, inflammation or metabolic stress and is therefore not generally expressed by normal tissues, thus limiting systemic adverse events

Macro, micro, and nano-inspired bioactive polymeric biomaterials in therapeutic, and regenerative orofacial applications