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597 In addition, bioinformatics analysis shows that Nrf2 is the target of FTO, and FTO impairs Nrf2 mRNA stability through an m6A dependent pathway, revealing the potential function of FTO in PD neurological diseases

In both humans and rodents, acute bouts of endurance exercise typically elevate circulating irisin levels by 23-fold, with reported concentrations ranging from ~3 to 10 ng/mL in serum 34

These factors include aging, poor diet, stress, pollution, and certain medical conditions

Finally, 20 articles met the inclusion criteria for this review

doi: 10.3389/fimmu.2022.913854 169 KhanMZLiuLZhangZKhanAWangDMiSet al

FIGURE 2 Recently, considerable evidence has accumulated suggesting a correlation between GM and AMD and its associated risks (Liu et al., 2023