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Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling

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PMID: 28850629

The activation of T cells with CD3 and CD28 increases EAATs expression levels and increases glutamine uptake by T cells ( + T cells enhance the uptake of glutamine through an increase in SLC1A5 expression ( The treatment of mice with xCT inhibitor or the genetic deletion of xCT significantly inhibited melanoma cell proliferation, however, the combination of xCT inhibition and anti-PD-1/PD-L1 therapy reduced the efficacy of anti-PD-1/anti-PD-L1 treatment in melanoma by impairing the cytotoxicity of CD8 + T cells and inducing M2 macrophage polarization