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Similar to ubiquitination, also SUMOylation occurs via a three-step cascade involving a single dimeric E1 enzyme, an E2 conjugating enzyme and E3 SUMO ligases attaching either SUMO1 or the highly related SUMO2/3 to the target

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Efficacy of axitinib in patients with metastatic renal cell carcinoma refractory to nivolumab therapy

[DOI] [PubMed] [Google Scholar] 43.Hamberg M

In ovarian cancer cell lines A2780 and SKOV-3, Agrimonolide not only restricts proliferation, migration, and invasion in a dose-dependent manner but also initiates apoptosis