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Matrix metalloproteinases (MMPs), a class of metalloendopeptidase produced by tumor cells and supportive cells, allow for the degradation of the basement membrane as well as the extracellular matrix surrounding pre-existing capillaries, typically postcapillary venules [30, 31]

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Pre-medication with a bronchodilator may be recommended in such cases.

This approach inhibits angiogenesis and weakens the self-renewal capacity of cancer cells, demonstrating great potential as a next-generation cancer therapy that reduces side effects and enhances efficacy (240, 241)

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nevertheless, the values measured in the CSF indicate that superficial skin abrasions of the head may be considered as residues of shearing movements of the head as head concussion, which may have promoted an increase of metabolites in the CSF before death