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Intracellular Activity: Unlike -MSH, which acts extracellularly, KPV enters cells and directly inhibits inflammatory signaling molecules within the nucleus

JCAHO accreditation and quality of care for acute myocardial infarction

Consider semaglutide if: You prioritize lower cost and established safety data You have a history of GI sensitivity and prefer gradual titration You want to start with the more affordable option (semaglutide at $299/month) You're seeking 15-18% weight loss with solid cardiovascular benefit Consider tirzepatide if: You have more aggressive weight loss goals (20%+ reduction) You have type 2 diabetes or significant cardiometabolic risk Cost is not a primary barrier You tolerate GI side effects well or are willing to manage them Many patients find success on either medication

Kohara K, Yasuda H, Huang Y, Adachi N, Sohya K, Tsumoto T (2007)

Skin elasticity, vascular health, and connective tissue integrity are all challenged during rapid weight loss

Can you just talk about what the evidence is about this and why its so crazy? Eric Topol: This is incredible to me