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NS, not stimulated

Recently, an increasing number of studies have demonstrated the important regulatory role played by epigenetic mechanisms, especially DNA, RNA, and protein methylation, in ferroptosis

Additionally, studies show that GPX4 inactivation induces hippocampal neuron death, while alpha-lipoic acid protects neurons by regulating GPX4 expression (Zhang YH

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We hypothesize that the selenium-iodine-induced oxidative eustress acts as a signal that shunts metabolic precursors away from the phenylpropanoid pathway (which produces eugenol) and toward the methylerythritol phosphate pathway, which leads to linalool synthesis