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Peer review Peer review information Nature Communications thanks Stephen Bourke, Rute Vieiraand and the other anonymous reviewer(s) for their contribution to the peer review of this work

In addition to its involvement in synaptic plasticity and transmission, free ARA plays a crucial role in neuroinflammation through its conversion into various eicosanoids by cyclooxygenases, prostaglandin synthases, and lipoxygenases, the activities of which have been associated with neurodegenerative diseases ( via cPLA2 induction can be metabolized by COX or LOXs ( Amino acid metabolism and alzheimers disease Amino acids play an important role in the occurrence and development of AD

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More structural improvementssuch as tendon integrity and joint stabilitytypically develop over 8-16 weeks