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38,39,46,54,55 Combination Preventive Therapy Up to 60% of patients achieve some improvement with preventive monotherapy, but approximately 30% fail to respond or cannot tolerate the available medications, especially the nonmigraine mechanism specific oral agents

Older age is a risk factor, as pernicious anemia is more common in individuals over 60

The Perceived Stress Scale (PSS) (171) is a widely used 10-item scale assessing the degree of appraisal of life situations as unpredictable and beyond control causing additional burden to an individual

VNS has previously been shown to alleviate chronic depression by modulating the HPA axis and reducing the CRH (corticotropin-releasing hormone)/ACTH (adrenocorticotropic hormone) response (95)

mRNA-based therapies provide a versatile tool for fine-tuning gene expression (Qin et al., 2022)

Darkness signals the nightly melatonin flood in the central nervous system, and with darkness creeping in more and more during autumn and winter, we naturally find more and prolonged central melatonin production