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Further selective reduction of one of the ester groups in 158 afforded S -21 in 85% yield, which was converted to R -ALA, according to a previously reported protocol

52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

Cardiovascular health

To obtain the cytoplasm and cytosol, the hearts were washed in ice-cold homogenisation buffer (250 mM sucrose, 10 mM HEPES, and 1 mM EGTA, pH 7.4), homogenised in 2 ml buffer and centrifuged at 700 g for 10 min at 4 C to remove unbroken tissue and nuclei

17 In contrast, unlocked nucleic acid (UNA) is a flexible RNA mimic that lacks chemical bonds between the ribose rings C2 and C3 atoms

Adipose tissue: an endocrine organ playing a role in metabolic regulation