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For example, involvement of TRPM4 in etiology of SCI was reported by result of recent papers (Gerzanich et al., Chemotherapy-induced peripheral neuropathy Many first-line chemotherapy agents used in the current clinical practice, such as platinum-based anticancer drugs (i.e., cisplatin, oxaliplatin), proteasome/angiogenesis inhibitors (bortezomib/thalidomide), vinca alkaloids (i.e., vincristine, vinorelbine) and taxanes (i.e., paclitaxel, docetaxel) cause a dose-limiting side effect called chemotherapy-induced peripheral neuropathy (CIPN) (Han and Smith, coasting