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Notch signaling dynamically regulates adult cell proliferation and maturity

Metabolic intermediates for biosynthesis Despite the original idea of Warburg [2] that aerobic glycolysis was originated as a consequence of mitochondrial dysfunction, subsequent studies showed that mitochondria of cancer cells are still functional and able to conduct oxidative phosphorylation

FEBS Lett 581:31313138 Gulyas Z, Boldizsar A, Novak A, Szalai G, Pal M, Galiba G, Kocsy G (2014) Central role of the flowering repressor ZCCT2 in the redox control of freezing tolerance and the initial development of flower primordia in wheat

Cancer cells often exhibit high expression of lipid receptors and transport proteins

Taken together, C32E8.9 is specifically required for mediating mitochondrial translation inhibition coupled with lifespan extension, without significantly altering the activation of the UPR mt

In a double-blind cross-over study of twenty infertile men, treatment with glutathione led to a statistically significant improvement of the sperm quality