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Although effective with supervised dosing, it is no longer first-line therapy due to poor adherence, variable efficacy, and hepatotoxicity concerns (168, 296)

164 It was proved that Temporin-1CEa could co-localize with P-gP on the surface of drug-resistant cell membranes, so the anticancer mechanism of Temporin-1CEa may be acting on P-gP and affecting its efflux function, thereby reversing multidrug resistance in tumor cells

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Born in 1937 in Preov, in eastern Slovakia, to Jewish parents, in September 1944, he and his family had to go into hiding, when the Nazis began deporting the last Jews to concentration camps as part of the 'Final Solution'

Salicin from Alangium chinense has anti-inflammatory effects, reduces ROS production by activating Nrf2/HO-1, and inhibits inflammatory factor secretion by FLSs in vivo and in vitro (258)