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Many chemotherapeutic drugs induce senescence in cancer cells and the tumor microenvironment

The results demonstrated that conditioned medium from MPP+-treated microglia substantially induced neuronal apoptosis and impaired cellular viability, whereas conditioned medium from irisin-treated microglia significantly reduced neuronal apoptosis and enhanced cell survival (Fig

A standardized step-wise evaluation, including IgG levels, autoantibodies serology, exclusion of viral etiologies, and liver biopsy, is recommended to ensure diagnostic accuracy and avoid unnecessary delays or misclassification

These products range from topical agents to those which can be taken orally

By contrast, GDIL overexpression increased 13 C-labeled cystine-derived GSH abundance but not that of precursors (Supplementary Fig

With no current treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions