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The third site is lateral to the second site

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Patients using PT-141 nasal spray often report variability in onset and effectiveness, which may be tied to environmental or physiological factors such as allergy season, nasal membrane dryness, or recent upper respiratory infections

Many notice decreased morning stiffness and reduced pain with first steps within the first week

doi:10.1016/S0021-9258(18)46868-8

The exact number depends on factors such as the amount of fat being targeted, individual response to treatment, and desired outcome